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PLoS Genet. 2017 Oct 5;13(10):e1006944. doi: 10.1371/journal.pgen.1006944. eCollection 2017 Oct.

Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges.

Author information

1
Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.

Abstract

The past decade has been proclaimed as a hugely successful era of gene discovery through the high yields of many genome-wide association studies (GWAS). However, much of the perceived benefit of such discoveries lies in the promise that the identification of genes that influence disease would directly translate into the identification of potential therapeutic targets, but this has yet to be realized at a level reflecting expectation. One reason for this, we suggest, is that GWAS, to date, have generally not focused on phenotypes that directly relate to the progression of disease and thus speak to disease treatment.

PMID:
28981501
PMCID:
PMC5628782
DOI:
10.1371/journal.pgen.1006944
[Indexed for MEDLINE]
Free PMC Article

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