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Ann Neurol. 2017 Oct;82(4):622-634. doi: 10.1002/ana.25060.

18 F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study.

Author information

1
Memory and Aging Center, University of California, San Francisco, San Francisco, CA.
2
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA.
3
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
4
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA.
5
Avid Radiopharmaceuticals, Philadelphia, PA.
6
Institute for Neurodegenerative Disorders, New Haven, CT.
7
Department of Neurology, University of California, San Diego, San Diego, CA.
8
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL.
9
Department of Pathology, University of California, San Francisco, San Francisco, CA.

Abstract

OBJECTIVE:

18 F-flortaucipir (formerly 18 F-AV1451 or 18 F-T807) binds to neurofibrillary tangles in Alzheimer disease, but tissue studies assessing binding to tau aggregates in progressive supranuclear palsy (PSP) have yielded mixed results. We compared in vivo 18 F-flortaucipir uptake in patients meeting clinical research criteria for PSP (n = 33) to normal controls (n = 46) and patients meeting criteria for Parkinson disease (PD; n = 26).

METHODS:

Participants underwent magnetic resonance imaging and positron emission tomography for amyloid-β (11 C-PiB or 18 F-florbetapir) and tau (18 F-flortaucipir). 18 F-flortaucipir standardized uptake value ratios were calculated (t = 80-100 minutes, cerebellum gray matter reference). Voxelwise and region-of-interest group comparisons were performed in template space, with receiver operating characteristic curve analyses to assess single-subject discrimination. Qualitative comparisons with postmortem tau are reported in 1 patient who died 9 months after 18 F-flortaucipir.

RESULTS:

Clinical PSP patients showed bilaterally elevated 18 F-flortaucipir uptake in globus pallidus, putamen, subthalamic nucleus, midbrain, and dentate nucleus relative to controls and PD patients (voxelwise p < 0.05 family wise error corrected). Globus pallidus binding best distinguished PSP patients from controls and PD (area under the curve [AUC] = 0.872 vs controls, AUC = 0.893 vs PD). PSP clinical severity did not correlate with 18 F-flortaucipir in any region. A patient with clinical PSP and pathological diagnosis of corticobasal degeneration had severe tau pathology in PSP-related brain structures with good correspondence between in vivo 18 F-flortaucipir and postmortem tau neuropathology.

INTERPRETATION:

18 F-flortaucipir uptake was elevated in PSP versus controls and PD patients in a pattern consistent with the expected distribution of tau pathology. Ann Neurol 2017;82:622-634.

PMID:
28980714
PMCID:
PMC5665658
DOI:
10.1002/ana.25060
[Indexed for MEDLINE]
Free PMC Article

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