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Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(6. Vyp. 2):33-40. doi: 10.17116/jnevro20171176233-40.

[Complex diagnostic of cognitive impairment].

[Article in Russian; Abstract available in Russian from the publisher]

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Kirov Military Medical Academy, St. Petersburg.


in English, Russian

In this article, the authors discussed the various aspects of pre-dementia stages of cognitive impairment, predominantly of neurodegenerative etiology. The modern conception of the pathophysiology of initial stages of cognitive impairment, the potential for lifetime pathological markers of amyloidosis and neurodegeneration are discussed. The authors proposed to use the concept of 'early signs of cognitive impairment'. The algorithm of the complex early diagnosis of cognitive impairment as well as the opportunities and prospects of clinical, neuropsychological, neuroimaging and laboratory examination methods are presented. The data on main diseases characterized by cognitive impairment and prospects for the use of new highly informative methods for early and differential diagnosis of Alzheimer's disease and vascular cognitive impairment are discussed.


Alzheimer’s disease; cognitive impairment; dementia; dementia biomarkers; early diagnosis; neuroimaging; vascular cognitive impairment

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