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Front Cell Neurosci. 2017 Sep 20;11:277. doi: 10.3389/fncel.2017.00277. eCollection 2017.

Serotonergic Control of Metabolic Homeostasis.

Author information

1
Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical CenterDallas, TX, United States.
2
Department of Pharmacology, UT Southwestern Medical CenterDallas, TX, United States.
3
Department of Neuroscience, UT Southwestern Medical CenterDallas, TX, United States.

Abstract

New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This review aims to synthesize pharmacological and genetic studies that have found diverse functions of both central and peripheral 5-HT in the control of food intake, thermogenesis, and glucose and lipid metabolism. We also discuss the potential benefits of targeting the 5-HT system to combat metabolic disease.

KEYWORDS:

adipose tissue; diabetes; feeding; gluconeogenesis; obesity; pancreas; serotonin

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