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Oncotarget. 2017 Jun 28;8(40):67663-67669. doi: 10.18632/oncotarget.18801. eCollection 2017 Sep 15.

MiR-200c inhibits bladder cancer progression by targeting lactate dehydrogenase A.

Author information

1
Department of Urology, Cancer Center of Guangzhou Medical University, Guangzhou, People's Republic of China.
2
Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, People's Republic of China.

Abstract

Lactate dehydrogenase A (LDHA) is overexpressed in various cancers. We investigated LDHA expression and function in bladder cancer. We demonstrate that LDHA is up-regulated in bladder cancer cells and promotes proliferation, invasion, and glycolysis. Additionally, we found that microRNA (miR)-200c directly targets LDHA in bladder cancer cells. Ectopic expression of miR-200c inhibited LDHA-induced glycolysis, cell proliferation, and invasion. Thus, targeting LDHA through miR-200c is a potential therapeutic strategy in bladder cancer.

KEYWORDS:

LDHA; bladder cancer; miR-200c; microRNA; proliferation

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that there are no conflicts of interest.

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