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Eur J Cardiothorac Surg. 2017 Dec 1;52(6):1206-1210. doi: 10.1093/ejcts/ezx152.

Lung cancer diagnosis by trained dogs.

Author information

1
Institut Respiratori, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
2
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
3
CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain.
4
ARGUS Detection Dogs, Barcelona, Spain.
5
Institut Clínic de Malalties Hematològiques i Oncològiques, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
6
Hospital Universitari Sagrat Cor, Barcelona, Spain.

Abstract

OBJECTIVES:

Early lung cancer (LC) diagnosis is key to improve prognosis. We explored here the diagnostic performance of a trained dog to discriminate exhaled gas samples obtained from patients with and patients without LC and healthy controls.

METHODS:

After appropriate training, we exposed the dog (a 3-year-old cross-breed between a Labrador Retriever and a Pitbull) to 390 samples of exhaled gas collected from 113 individuals (85 patients with LC and 28 controls, which included 11 patients without LC and 17 healthy individuals) for a total of 785 times.

RESULTS:

The trained dog recognized LC in exhaled gas with a sensitivity of 0.95, a specificity of 0.98, a positive predictive value of 0.95 and a negative predictive value of 0.98. The area under the curve of the receiver-operating characteristics curve was 0.971.

CONCLUSIONS:

This study shows that a well-trained dog can detect the presence of LC in exhaled gas samples with an extremely high accuracy.

KEYWORDS:

Exhaled gas; Lung cancer diagnosis; Smoking; Volatile organ compounds

Comment in

PMID:
28977566
DOI:
10.1093/ejcts/ezx152
[Indexed for MEDLINE]

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