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Autophagy. 2018;14(6):1082-1083. doi: 10.1080/15548627.2017.1382784. Epub 2018 Feb 3.

WIPI β-propellers function as scaffolds for STK11/LKB1-AMPK and AMPK-related kinase signaling in autophagy.

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a Department of Molecular Biology, Interfaculty Institute of Cell Biology , Eberhard Karls University Tuebingen , Germany.
b International Max Planck Research School 'From Molecules to Organisms' , Max Planck Institute for Developmental Biology and Eberhard Karls University Tuebingen , Germany.


The article discusses new findings on the role of the 4 human WIPI proteins at the onset of macroautophagy/autophagy. New insights revealing a circuit scaffold function of WIPI β-propellers that interconnect autophagy signaling control with appropriate autophagosome formation are summarized.


WIPI1; WIPI2; WIPI3; WIPI4; autophagy

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