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Pharmacogenomics. 2017 Oct;18(15):1387-1391. doi: 10.2217/pgs-2017-0092. Epub 2017 Oct 4.

The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment.

Author information

1
The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, NY, 10065, USA.
2
Dr Miriam & Sheldon G Adelson Clinic for Drug Abuse Treatment & Research, Tel Aviv Elias Sourasky Medical Center, 1 Henrietta Szold St, Tel-Aviv, 64924, Israel.
3
Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel.
4
Center for Clinical & Translational Science, The Rockefeller University, NY, 10065, USA.
5
Dr Miriam & Sheldon G Adelson Clinic for Drug Abuse Treatment & Research, Las Vegas, NV, 89169, USA.

Abstract

AIM:

This study assesses whether opioid-related gene variants contribute to reduced vulnerability to relapse to heroin in persons who are not treated with μ-opioid receptor agonist.

METHODS:

Genotypes of 71 SNPs, in nine genes, were analyzed for association with long-term abstinence in former heroin-dependents of European/Middle Eastern ancestry, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 922).

RESULTS:

The functional OPRM1 nonsynonymous SNP rs1799971 (118A>G) showed significant association with long-term abstinence (Ppermutation  = 0.03, dominant model, OR: 2.2; 95% CI: 1.5-3.3).

CONCLUSION:

Since the stress axis is regulated in part by β-endorphin, this functional OPRM1 SNP may blunt the endogenous stress response and contribute to reduced vulnerability for relapse.

KEYWORDS:

HPA axis; abstinence; heroin addiction; opioids; rs1799971; stress; μ-opioid receptor

PMID:
28976288
DOI:
10.2217/pgs-2017-0092
[Indexed for MEDLINE]

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