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J Exp Ther Oncol. 2017 Sep;11(2):101-105.

Diffuse large B cell lymphoma of hard palate: a case report with literature review.

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Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Bareilly-243006, Uttar Pradesh State, India.
Department of Oral Biology, Faculty of Dentistry, Taif University, Taif, Kingdom of Saudi Arabia.


Lymphomas are diverse group of neoplasm affecting the lymphoreticular system. Diffuse large B cell lymphoma is the most frequently diagnosed type of non-Hodgkin lymphoma and is the fifth most frequent malignancy, accounting for about 40% of cases reported. In the present case report a 40 year old female patient complains of swelling on right side of face since 45 days and gradually increased to present size. Intra-orally an ulcero-proliferative growth was present on the right side of hard palate. Incisional biopsy was suggestive of Lymphoproliferative disorder. Panel of immunohistochemical antibodies were used; which showed positivity for CD45, PAX5, Bcl2, Ki67, CD138 and negativity for CD3, CD10, CD20 and CD30. Therefore through routine standard hematoxylin and eosin staining a clear cut diagnosis of specific lymphoma was difficult to obtain and thus immunohistochemistry plays an important role in confirming the pinpoint diagnosis.


B cells; Bcl2; CD10; CD45; Immunohistochemistry; Non- Hodgkin’s lymphoma; Oral diffuse large B cell lymphoma

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