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Eur J Nutr. 2018 Dec;57(8):2785-2794. doi: 10.1007/s00394-017-1544-6. Epub 2017 Oct 3.

Calcium and vitamin D fortified milk reduces bone turnover and improves bone density in postmenopausal women over 1 year.

Author information

1
School of Food and Nutrition, Massey University, Private Bag 11222, Palmerston North, 4442, New Zealand. m.c.kruger@massey.ac.nz.
2
Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
3
Malaysian Research Institute on Ageing, Universiti Putra Malaysia, Serdang, Malaysia.
4
Research Centre of Excellence for Nutrition and Non-Communicable Diseases, Universiti Putra Malaysia, Serdang, Malaysia.
5
BKS Statistical Consulting, Hamilton, New Zealand.
6
Fonterra Cooperative Ltd, Auckland, New Zealand.
7
Fonterra Research and Development Centre, Palmerston North, New Zealand.

Abstract

PURPOSE:

In Malaysia, hip fracture incidence is higher in Chinese women than other ethnic groups. This study compared the effects of a high-calcium vitamin D fortified milk with added FOS-inulin versus regular milk over 1 year on aspects of bone health in Chinese postmenopausal women in Malaysia.

METHODS:

One-hundred and twenty-one women (mean age 59 (± 4) years) were randomized into two groups: control (n = 60; regular milk, 428 mg calcium per day) or intervention (n = 61; fortified milk at 1200 mg calcium, 96 mg magnesium, 2.4 mg zinc, 15 μg vitamin D and 4 g FOS-inulin per day). At baseline, weeks 12, 24, 36 and 52, parathyroid hormone (PTH), C-Telopeptide of Type I Collagen (CTx-1), Procollagen I Intact N-Terminal propeptide (PINP) and vitamin D levels were assessed. Bone density (BMD) was measured at baseline and week 52 using a GE Lunar iDXA.

RESULTS:

Body mass index, lumbar spine and femoral neck BMD did not differ between groups at baseline. Over 52 weeks, mean plasma 25 (OH) D3 levels increased to 74.8 nmol/L (intervention group) or remained at 63.1 nmol/L (control group) (p < 0.001 between groups). PTH levels increased in the control group (p = 0.001). The intervention resulted in a significant suppression of CTx-1 and PINP at p = 0.018 and p = 0.004. Femoral neck BMD remained stable in the intervention group but decreased significantly in the controls, with a borderline treatment effect (p = 0.07).

CONCLUSION:

Compared with regular milk, the fortified milk suppressed bone turnover markers and tended to increase femoral neck BMD.

KEYWORDS:

Bone density; Bone markers; Fortified milk; Postmenopausal women

PMID:
28975432
DOI:
10.1007/s00394-017-1544-6
[Indexed for MEDLINE]

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