Format

Send to

Choose Destination
See comment in PubMed Commons below
Lancet. 1988 Jun 4;1(8597):1252-5.

Loss of matrix calcium-binding protein-containing neurons in Huntington's disease.

Author information

1
MRC Group, AFRC, Institute of Animal Physiology and Genetics Research, Babraham, Cambridge.

Abstract

In post-mortem brain specimens from patients dying with a clinical diagnosis of Huntington's disease (HD) immunohistochemistry showed a substantial loss from the neostriatum of neurons containing the calcium-binding protein calbindin 28K. These calbindin neurons, and the straital compartment in which they are sited, are particularly damaged in HD, suggesting that a failure of calcium buffering or homeostasis may contribute to cell death in HD.

PMID:
2897519
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center