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J Nanobiotechnology. 2017 Oct 3;15(1):65. doi: 10.1186/s12951-017-0308-z.

Metal nanoparticles: understanding the mechanisms behind antibacterial activity.

Author information

1
Department of Medicine, Division of Infectious Diseases, University of British Columbia, 410-2660 Oak St., Vancouver, BC, V6H3Z6, Canada.
2
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
3
Department of Medicine, Division of Infectious Diseases, University of British Columbia, 410-2660 Oak St., Vancouver, BC, V6H3Z6, Canada. hbach@mail.ubc.ca.

Abstract

As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed.

KEYWORDS:

Antibacterial resistance; Bacteria; Gene regulation; Mechanism of defense; Metals; Nanoparticles; Proteomics; ROS; Transcriptomics

PMID:
28974225
PMCID:
PMC5627441
DOI:
10.1186/s12951-017-0308-z
[Indexed for MEDLINE]
Free PMC Article

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