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Neurosurgery. 2018 Jun 1;82(6):770-780. doi: 10.1093/neuros/nyx357.

Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol.

Author information

1
Department of Neurology, Oregon Health & Science University, Portland, Oregon.
2
Department of Neuroradiology, Oregon Health & Science University, Portland, Oregon.
3
Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, Oregon.
4
Human Health Therapeutics Portfolio, National Research Council of Canada, Ottawa, Ontario, Canada.
5
Department of Radiology, University of Washington, Seattle, Washington.
6
Department of Radiology, Oregon Health & Science University, Portland, Oregon.
7
Department of Neurosurgery, University of New Mexico, Albuquerque, New Mexico.
8
Department of Radiology, Stanford University, Stanford, California.
9
Department of Radiology, University of Calgary, Foothills Medical Center, Calgary, Alberta, Canada.
10
Zikha Neurogenetic Institute, University of Southern California, Los Angeles, California.
11
Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland.
12
Department of Radiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
13
Department of Radiology and Radiological Sciences, Medical University of South Carolina, Charleston, South Carolina.
14
Department of Radiology and Neurosurgery, New York University School of Medicine, New York, New York.
15
Department of Radiology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
16
Translational Neuroradiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
17
Department of Biomedical Sciences, University of Minnesota, Duluth, Minnesota.
18
Department of Neurosurgery, Oregon Health & Science University, Portland, Oregon.
19
Portland Veterans Affairs Medical Center, Portland, Oregon.

Abstract

Physiological and pathological processes that increase or decrease the central nervous system's need for nutrients and oxygen via changes in local blood supply act primarily at the level of the neurovascular unit (NVU). The NVU consists of endothelial cells, associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymal cells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essential for interpretation of central nervous system physiology and pathology as revealed by conventional and advanced imaging techniques. This article reviews current strategies for interrogating the NVU, focusing on vascular permeability, blood volume, and functional imaging, as assessed by ferumoxytol an iron oxide nanoparticle.

PMID:
28973554
PMCID:
PMC6256943
DOI:
10.1093/neuros/nyx357
[Indexed for MEDLINE]
Free PMC Article

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