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PLoS One. 2017 Oct 3;12(10):e0185413. doi: 10.1371/journal.pone.0185413. eCollection 2017.

Evaluation of obstructive sleep apnea in non-cystic fibrosis bronchiectasis: A cross-sectional study.

Author information

1
Master's degree and PhD Program in Surgery Research, Santa Casa de Sao Paulo School of Medical Sciences, (FCMSCSP), Sao Paulo (SP), Brazil.
2
Rehabilitation Sciences Master's degree and PhD Program, Nove de Julho University (UNINOVE), Sao Paulo (SP), Brazil.
3
Pulmonary Rehabilitation Center, Federal University of Sao Paulo, (UNIFESP), Sao Paulo (SP), Brazil.
4
National Research Council of Italy-Institute of Biomedicine and Molecular Immunology "Alberto Monroy", Palermo (SI), Italy.
5
Medicine School, University Center of Anapolis (UniEVANGELICA), Anapolis (GO), Brazil.

Abstract

The relationship between sleep disorders and bronchiectasis has not been well described. We hypothesize that, due to the irreversible dilatation of the bronchi, the presence of secretions, and airflow obstruction, patients with non-cystic fibrosis bronchiectasis may be predisposed to hypoxemia during sleep, or to symptoms that may lead to arousal. A cross-sectional observational study was performed involving 49 patients with a clinical diagnosis of non-cystic fibrosis bronchiectasis (NCFB). All patients underwent clinical evaluation, spirometry, and polysomnography, and were evaluated for the presence of excessive daytime sleepiness (EDS) and risk of obstructive sleep apnea (OSA). The mean age of the participants was 50.3 ± 13.6 years; 51.1% of patients were male and had a mean body mass index of 23.8 ± 3.4 kg/m2. The mean total sleep time (TST) was 325.15 ± 64.22 min with a slight reduction in sleep efficiency (84.01 ± 29.2%). Regarding sleep stages, stage 1 sleep and REM sleep were abnormal. OSA was present in 40.82% of the patients. The mean arousal index was 5.6 ± 2.9/h and snoring was observed in 71.43% of the patients. The oxygen desaturation index (ODI) was 14.35 ± 15.36/h, mean minimum oxygen saturation (SpO2 nadir) was 83.29 ± 7.99%, and mean TST with an SpO2 less than 90% was 30.21 ± 60.48 min. EDS was exhibited by 53.06% of the patients and 55.1% were at high risk of developing OSA. The patients infected by Pseudomonas aeruginosa had higher apnea-hypopnea indices, ODI, and TST with SpO2 < 90%, and lower values of SpO2 nadir. Adult patients with clinically stable NCFB, especially those infected by Pseudomonas aeruginosa, display EDS and a high prevalence of OSA, associated with considerable oxygen desaturation during sleep.

PMID:
28972989
PMCID:
PMC5626030
DOI:
10.1371/journal.pone.0185413
[Indexed for MEDLINE]
Free PMC Article

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