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Expert Rev Vaccines. 2018 Jan;17(1):99-102. doi: 10.1080/14760584.2018.1388168. Epub 2017 Oct 13.

Absence of association between Guillain-Barré syndrome hospitalizations and HPV-vaccine.

Author information

1
a Quebec University Hospital Research Centre , Université Laval , Québec , QC , Canada.
2
b Department of Occupational and Biological Risks , Institut national de santé publique du Québec , Québec , QC , Canada.

Abstract

BACKGROUND:

In 2008, a school-based human papilloma virus (HPV) vaccination program was implemented in the province of Québec. Grade 4 girls (9-10 years old) are routinely vaccinated and grade 9 to 12 girls (14-17 years old) were eligible for the catch-up vaccination. Vaccine coverage of the targeted cohorts was estimated at 76-81%. To assess if HPV vaccination is associated with an increase in GBS hospitalisation, we compared the hospitalization rates of GBS in HPV vaccination targeted and non-targeted groups.

METHODS:

Hospital discharge records with a GBS code as the main diagnosis during the 1999-2014 period were retrieved. Incidence rates according to program eligibility were computed and adjusted relative risk in the targeted groups was estimated by Poisson regression.

RESULTS:

The overall incidence rate in the 7 to 17 year-olds was 0.73/100,000 p-y. There was no increase in GBS incidence in HPV vaccination targeted groups (adjusted IRR = 0.81, 95%CI: 0.29-2.26).

CONCLUSION:

No signal of increase GBS hospitalisation incidence in the HPV-vaccine targeted group was detected in the hospitalisation database.

KEYWORDS:

Guillain-Barré syndrome; human papilloma virus; immunization; safety; vaccine

PMID:
28972438
DOI:
10.1080/14760584.2018.1388168
[Indexed for MEDLINE]

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