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Future Microbiol. 2017 Oct;12:1219-1237. doi: 10.2217/fmb-2017-0013. Epub 2017 Sep 15.

Immune escape strategies of Borrelia burgdorferi.

Author information

1
Department of Microbiology, Government College University, Faisalabad, Pakistan.
2
College of Allied Health Professionals, Directorate of Medical Sciences, Government College University, Faisalabad, Pakistan.
3
Neurobiology Division, The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, Scotland, UK.

Abstract

The borrelial resurge demonstrates that Borrelia burgdorferi is a persistent health problem. This spirochete is responsible for a global public health concern called Lyme disease. B. burgdorferi faces diverse environmental conditions of its vector and host during its life cycle. To circumvent the host immune system is a prominent feature of B. burgdorferi. To date, numerous studies have reported on the various mechanisms used by this pathogen to evade the host defense mechanisms. This current review attempts to consolidate this information to describe the immunological and molecular methods used by B. burgdorferi for its survival.

KEYWORDS:

Borrelia burgdorferi; immune evasion; spirochete

PMID:
28972415
DOI:
10.2217/fmb-2017-0013
[Indexed for MEDLINE]

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