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J Asian Nat Prod Res. 2017 Nov;19(11):1079-1086. doi: 10.1080/10286020.2017.1381687. Epub 2017 Oct 3.

Constituents from Apium graveolens and their anti-inflammatory effects.

Author information

1
a Key Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Wuya College of Innovation, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
2
b School of Pharmacy , Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China.

Abstract

A phthalide glycoside, (3R, 4R)-4-O-β-D-glucopyranosyl-senkyunolide (1), and a megastigmane glycoside, (6S, 7R)-3-oxo-megastigma-4, 8-dien-7-O-β-D-glucoside (2), along with two known aglycones (3-4), were isolated from the 70% EtOH extract of fresh whole grass of Apium graveolens L. Their structures were elucidated by extensive spectroscopic analysis. All of these compounds were tested for their inhibitory effects on nitric oxide (NO) production in the RAW 264.7 macrophages. Among them, compounds 3 and 4 showed potent inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages, with IC50 values of 24.0 ± 2.1 μM and 28.6 ± 2.4 μM, respectively.

KEYWORDS:

Apium graveolens; megastigmane glycoside; nitric oxide; phthalide glycoside

PMID:
28971709
DOI:
10.1080/10286020.2017.1381687
[Indexed for MEDLINE]

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