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Mol Imaging Biol. 2018 Oct;20(5):716-731. doi: 10.1007/s11307-017-1126-2.

Standardization of Small Animal Imaging-Current Status and Future Prospects.

Author information

1
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Roentgenweg 13, 72076, Tuebingen, Germany. julia.mannheim@med.uni-tuebingen.de.
2
Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium.
3
Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
4
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Roentgenweg 13, 72076, Tuebingen, Germany.
5
Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Aachen, Germany.
6
Optical Molecular Imaging, Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands.
7
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.

Abstract

The benefit of small animal imaging is directly linked to the validity and reliability of the collected data. If the data (regardless of the modality used) are not reproducible and/or reliable, then the outcome of the data is rather questionable. Therefore, standardization of the use of small animal imaging equipment, as well as of animal handling in general, is of paramount importance. In a recent paper, guidance for efficient small animal imaging quality control was offered and discussed, among others, the use of phantoms in setting up a quality control program (Osborne et al. 2016). The same phantoms can be used to standardize image quality parameters for multi-center studies or multi-scanners within center studies. In animal experiments, the additional complexity due to animal handling needs to be addressed to ensure standardized imaging procedures. In this review, we will address the current status of standardization in preclinical imaging, as well as potential benefits from increased levels of standardization.

KEYWORDS:

Animal handling; CT; MRI; OI; PET; Reliability; Reproducibility; SPECT; Small animal imaging; Standardization

PMID:
28971332
DOI:
10.1007/s11307-017-1126-2
[Indexed for MEDLINE]

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