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Trends Plant Sci. 2017 Nov;22(11):949-960. doi: 10.1016/j.tplants.2017.08.006. Epub 2017 Sep 29.

Plant Systems Biology at the Single-Cell Level.

Author information

1
Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, USA. Electronic address: libaultm@ou.edu.
2
Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, USA.
3
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

Abstract

Our understanding of plant biology is increasingly being built upon studies using 'omics and system biology approaches performed at the level of the entire plant, organ, or tissue. Although these approaches open new avenues to better understand plant biology, they suffer from the cellular complexity of the analyzed sample. Recent methodological advances now allow plant scientists to overcome this limitation and enable biological analyses of single-cells or single-cell-types. Coupled with the development of bioinformatics and functional genomics resources, these studies provide opportunities for high-resolution systems analyses of plant phenomena. In this review, we describe the recent advances, current challenges, and future directions in exploring the biology of single-cells and single-cell-types to enhance our understanding of plant biology as a system.

KEYWORDS:

-omics; Plant single-cell; computational modeling; system biology

PMID:
28970001
DOI:
10.1016/j.tplants.2017.08.006
[Indexed for MEDLINE]

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