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Trends Neurosci. 2017 Nov;40(11):654-666. doi: 10.1016/j.tins.2017.09.001. Epub 2017 Sep 29.

Estradiol Membrane-Initiated Signaling in the Brain Mediates Reproduction.

Author information

1
Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles (UCLA), and Laboratory of Neuroendocrinology of the UCLA Brain Research Institute, Los Angeles, CA 90095, USA. Electronic address: pmicevych@mednet.ucla.edu.
2
Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
3
Department of Biological Sciences, California State University, Long Beach, Long Beach, CA 90840, USA.

Abstract

Over the past few years our understanding of estrogen signaling in the brain has expanded rapidly. Estrogens are synthesized in the periphery and in the brain, acting on multiple receptors to regulate gene transcription, neural function, and behavior. Various estrogen-sensitive signaling pathways often operate in concert within the same cell, increasing the complexity of the system. In females, estrogen concentrations fluctuate over the estrous/menstrual cycle, dynamically modulating estrogen receptor (ER) expression, activity, and trafficking. These dynamic changes influence multiple behaviors but are particularly important for reproduction. Using the female rodent model, we review our current understanding of estradiol signaling in the regulation of sexual receptivity.

KEYWORDS:

ERα; GPER; caveolin; estrogen feedback; lordosis behavior; mGluR

PMID:
28969926
PMCID:
PMC5744592
DOI:
10.1016/j.tins.2017.09.001
[Indexed for MEDLINE]
Free PMC Article

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