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Oncotarget. 2017 Mar 11;8(38):64449-64458. doi: 10.18632/oncotarget.16136. eCollection 2017 Sep 8.

Impact of preoperative thrombocytosis on prognosis after surgical treatment in pathological T1 and T2 renal cell carcinoma: results of a multi-institutional comprehensive study.

Author information

1
Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea.
2
Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
3
Department of Urology, Chonnam National University Hwasun Hospital, Jeonnam, Korea.
4
Department of Urology, Korea University School of Medicine, Seoul, Korea.
5
Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
6
Department of Urology, National Cancer Center, Goyang, Korea.
7
Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
8
Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.

Abstract

BACKGROUND:

The prognostic significance of preoperative thrombocytosis (TC) in renal cell carcinoma (RCC) is not without some debate. The aim of the present multi-institutional study was to determine the association of preoperative TC with the clinicopathological features and prognosis of localized RCC patients who underwent surgery in a large cohort.

METHODS:

A study involving 8 institutions, and 4,376 patients with pT1 and pT2 RCC from the Korean renal cell carcinoma (KORCC) database, was conducted. TC was defined as a platelet count ≥400,000/μL. Patients were divided into 2 groups based on the presence of preoperative TC. Clinicopathological variables and survival rates were compared between the 2 groups.

RESULTS:

Out of the 4,376 patients in the study, 106 (2.4%) had preoperative TC. Compared to patients without TC, these patients had a lower body mass index. Additionally, these patients had more advanced stage tumors with a higher Fuhrman grade, and higher incidence of symptoms at the time of diagnosis. Kaplan-Meier curves revealed that patients with TC had a significantly lower rate of recurrence-free survival (RFS). Furthermore, a lower rate of overall survival (OS) was exhibited amongst patients with TC. Multivariate analysis revealed that TC was an independent prognostic factor in terms of the RFS and OS.

CONCLUSIONS:

TC appeared to be an important prognostic determinant in localized RCC. Furthermore, preoperative platelet count may be clinically useful for risk stratification of patients with surgically treated localized RCC.

KEYWORDS:

prognosis; renal cell carcinoma; thrombocytosis

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that there are no conflicts of interest associated with the publication of this manuscript.

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