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Oncotarget. 2017 Mar 11;8(38):64449-64458. doi: 10.18632/oncotarget.16136. eCollection 2017 Sep 8.

Impact of preoperative thrombocytosis on prognosis after surgical treatment in pathological T1 and T2 renal cell carcinoma: results of a multi-institutional comprehensive study.

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Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea.
Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Department of Urology, Chonnam National University Hwasun Hospital, Jeonnam, Korea.
Department of Urology, Korea University School of Medicine, Seoul, Korea.
Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Urology, National Cancer Center, Goyang, Korea.
Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.



The prognostic significance of preoperative thrombocytosis (TC) in renal cell carcinoma (RCC) is not without some debate. The aim of the present multi-institutional study was to determine the association of preoperative TC with the clinicopathological features and prognosis of localized RCC patients who underwent surgery in a large cohort.


A study involving 8 institutions, and 4,376 patients with pT1 and pT2 RCC from the Korean renal cell carcinoma (KORCC) database, was conducted. TC was defined as a platelet count ≥400,000/μL. Patients were divided into 2 groups based on the presence of preoperative TC. Clinicopathological variables and survival rates were compared between the 2 groups.


Out of the 4,376 patients in the study, 106 (2.4%) had preoperative TC. Compared to patients without TC, these patients had a lower body mass index. Additionally, these patients had more advanced stage tumors with a higher Fuhrman grade, and higher incidence of symptoms at the time of diagnosis. Kaplan-Meier curves revealed that patients with TC had a significantly lower rate of recurrence-free survival (RFS). Furthermore, a lower rate of overall survival (OS) was exhibited amongst patients with TC. Multivariate analysis revealed that TC was an independent prognostic factor in terms of the RFS and OS.


TC appeared to be an important prognostic determinant in localized RCC. Furthermore, preoperative platelet count may be clinically useful for risk stratification of patients with surgically treated localized RCC.


prognosis; renal cell carcinoma; thrombocytosis

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that there are no conflicts of interest associated with the publication of this manuscript.

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