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J Infect Dis. 2017 Nov 15;216(8):977-980. doi: 10.1093/infdis/jix428.

Measles Virus Neutralizing Antibodies in Intravenous Immunoglobulins: Is an Increase by Revaccination of Plasma Donors Possible?

Author information

1
Global Pathogen Safety, Shire, Vienna, Austria.
2
BioLife Quality/Regulatory, Shire, Bannockburn, Illinois.
3
CSL Plasma Laboratory, Knoxville, Tennessee.
4
CSL Plasma, Boca Raton, Florida.

Abstract

We report a screen of plasma donors confirming that widespread use of childhood measles vaccination since 1963 resulted in a decrease in average measles virus antibody titers among plasma donors, which is reflected in intravenous immunoglobulins (IVIGs). The measles virus antibody titer, however, is a potency requirement for IVIGs, as defined in a Food and Drug Administration regulation. To mitigate the decline in measles virus antibody titers in IVIGs and to ensure consistent product release, revaccination of plasma donors was investigated as a means to boost titers. However, revaccination-induced titer increases were only about 2-fold and short-lived.

KEYWORDS:

FDA regulation 21 CFR 640.104; Primary immunodeficiency; antibody boost; intravenous immune globulin; measles vaccination; measles virus antibody titer; titer decline

PMID:
28968738
DOI:
10.1093/infdis/jix428
[Indexed for MEDLINE]

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