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Ann Diagn Pathol. 2017 Oct;30:42-46. doi: 10.1016/j.anndiagpath.2017.05.010. Epub 2017 May 16.

Dedifferentiated chondrosarcoma of the larynx: Radiological, gross, microscopic and clinical features.

Author information

1
Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA 30308, USA. Electronic address: kmagliocca@emory.edu.
2
Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA 30308, USA.
3
Department of Radiology and Imaging Sciences, Emory University 1364 Clifton Road, NE Atlanta, GA 30322, USA.
4
Department of Otolaryngology, Emory University Hospital, Atlanta, GA 30308, USA.

Abstract

Laryngeal chondrosarcoma is an uncommon malignancy with a predilection for the cricoid cartilage of adult male patients. Although rare, identification of aggressive chondrosarcoma variants, such as dedifferentiated chondrosarcoma (DDCS) may influence preoperative patient counseling, definitive surgical management, potential implementation of post-operative adjuvant therapy and prognosis. Herein we describe clinical and imaging features of laryngeal DDCS, the unique perspective of fresh and formalin fixed macroscopic examination, a spectrum of histopathologic findings, and detail the full course of the patient's disease.

KEYWORDS:

Chondrosarcoma; Dedifferentiated; Gross examination; Larynx; Metastasis

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