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Plant Foods Hum Nutr. 2017 Dec;72(4):445-447. doi: 10.1007/s11130-017-0633-2.

Dietary Peptides from Phaseolus vulgaris L. Reduced AOM/DSS-Induced Colitis-Associated Colon Carcinogenesis in Balb/c Mice.

Author information

1
Programa de Posgrado en Alimentos del Centro de la Republica (PROPAC), Universidad Autónoma de Querétaro, Santiago de Querétaro, Mexico.
2
Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
3
Programa de Posgrado en Alimentos del Centro de la Republica (PROPAC), Universidad Autónoma de Querétaro, Santiago de Querétaro, Mexico. loarca@uaq.mx.

Abstract

The aim was to evaluate the antineoplastic potential of a previously characterized peptide extract from the non-digestible fraction of common bean cv. Azufrado Higuera (AH) and its most abundant pure peptide GLTSK, in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colitis-associated colon carcinogenesis Balb/c mice model. The healthy control (C-) had no induction and no treatment, and the induced control (C+) had induction but no treatment. Groups AH and GLTSK were administered 50 mg/kg-bw of AH or GLTSK, respectively. The administration of AH and GLTSK decreased (p < 0.05) the disease activity index (DAI) compared to C+ (5.8, 9.1, 11.8, respectively). Furthermore, AH reduced the number of evident neoplasms compared to group C+ (1.8, 5.9 neoplasms/mice, respectively). The results suggest that peptides from common bean cv. Azufrado Higuera could prevent colitis-associated colon carcinogenesis.

KEYWORDS:

Anticancer peptides; Bioactive peptides; Colon carcinogenesis; Common bean

PMID:
28965253
DOI:
10.1007/s11130-017-0633-2
[Indexed for MEDLINE]

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