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Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):274-284. doi: 10.1016/j.ijrobp.2017.05.044. Epub 2017 Jun 9.

Precision Oncology and Genomically Guided Radiation Therapy: A Report From the American Society for Radiation Oncology/American Association of Physicists in Medicine/National Cancer Institute Precision Medicine Conference.

Author information

1
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Radiation Oncology, Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin. Electronic address: whall@mcw.edu.
2
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Radiation Oncology, Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin.
3
Department of Radiation Medicine and Computational Biology Program, Oregon Health & Science University, Portland, Oregon; Division of Hospital and Specialty Medicine, VA Portland Health Care System, Portland, Oregon.
4
Department of Human Oncology, University of Wisconsin Madison, Madison, Wisconsin.
5
Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, Mississippi.
6
Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.
7
Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan.
8
Translational Radiation Biology, University of Manchester, The Christie NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
9
Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
10
Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida.
11
Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California.
12
Departments of Radiation Oncology, Urology, and Medicine and the Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.

Abstract

PURPOSE:

To summarize important talking points from a 2016 symposium focusing on real-world challenges to advancing precision medicine in radiation oncology, and to help radiation oncologists navigate the practical challenges of precision, radiation oncology.

METHODS AND MATERIALS:

The American Society for Radiation Oncology, American Association of Physicists in Medicine, and National Cancer Institute cosponsored a meeting on precision medicine in radiation oncology. In June 2016 numerous scientists, clinicians, and physicists convened at the National Institutes of Health to discuss challenges and future directions toward personalized radiation therapy. Various breakout sessions were held to discuss particular components and approaches to the implementation of personalized radiation oncology. This article summarizes the genomically guided radiation therapy breakout session.

RESULTS:

A summary of existing genomic data enabling personalized radiation therapy, ongoing clinical trials, current challenges, and future directions was collected. The group attempted to provide both a current overview of data that radiation oncologists could use to personalize therapy, along with data that are anticipated in the coming years. It seems apparent from the provided review that a considerable opportunity exists to truly bring genomically guided radiation therapy into clinical reality.

CONCLUSIONS:

Genomically guided radiation therapy is a necessity that must be embraced in the coming years. Incorporating these data into treatment recommendations will provide radiation oncologists with a substantial opportunity to improve outcomes for numerous cancer patients. More research focused on this topic is needed to bring genomic signatures into routine standard of care.

PMID:
28964588
DOI:
10.1016/j.ijrobp.2017.05.044
[Indexed for MEDLINE]

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