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Eur J Med Chem. 2017 Dec 15;142:486-492. doi: 10.1016/j.ejmech.2017.09.013. Epub 2017 Sep 15.

Beta-glucans and cancer: The influence of inflammation and gut peptide.

Author information

1
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, 90128, Italy.
2
Dipartimento di Biopatologia e Biotecnologie Mediche (Di.Bi.Med), University of Palermo, Italy.
3
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, 90128, Italy; Institute of Biomedicine and Molecular Immunology "Alberto Monroy", CNR, Palermo, Italy. Electronic address: sonya.vasto@unipa.it.

Abstract

Dietary β-glucans are soluble fibers with potentially health-promoting effects. Gut peptides are important signals in the regulation of energy and glucose homeostasis. This article reviews the effects of different enriched β-glucan food consumption on immune responses, inflammation, gut hormone and cancer. Gut hormones are influenced by enriched β-glucan food consumption and levels of such peptide as YY, ghrelin, glucagon-like peptide 1 and 2 in humans influence serum glucose concentration as well as innate and adaptive immunity. Cancer cell development is also regulated by obesity and glucose dishomeostasy that are influenced by β-glucan food consumption that in turn regulated gut hormones.

KEYWORDS:

Cancer; GLP-1; GLP-2; Ghrelin; Glucose; Inflammation; Insulin; PYY; β-Glucans

PMID:
28964548
DOI:
10.1016/j.ejmech.2017.09.013
[Indexed for MEDLINE]

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