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J Am Acad Dermatol. 2017 Dec;77(6):1023-1029. doi: 10.1016/j.jaad.2017.08.034. Epub 2017 Sep 28.

Cardiovascular comorbidities of pediatric psoriasis among hospitalized children in the United States.

Author information

1
Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
2
Departments of Dermatology, Preventive Medicine, and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address: jonathanisilverberg@gmail.com.

Abstract

BACKGROUND:

Psoriasis has been shown to be associated with cardiovascular disease in adults. Little is known about cardiovascular risk in pediatric psoriasis.

OBJECTIVE:

To determine if there is an association between pediatric psoriasis and cardiovascular comorbidities.

METHODS:

Data were analyzed from the 2002-2012 Nationwide Inpatient Sample, which included 4,884,448 hospitalized children aged 0-17 years. Bivariate and multivariate survey logistic regression models were created to calculate the odds of psoriasis on cardiovascular comorbidities.

RESULTS:

In multivariate survey logistic regression models adjusting for age, sex, and race/ethnicity, pediatric psoriasis was significantly associated with 5 of 10 cardiovascular comorbidities (adjusted odds ratio [95% confidence interval]), including obesity (3.15 [2.46-4.05]), hypertension (2.63 [1.93-3.59]), diabetes (2.90 [1.90-4.42]), arrhythmia (1.39 [1.02-1.88]), and valvular heart disease (1.90 [1.07-3.37]). The highest odds of cardiovascular risk factors occurred in blacks and Hispanics and children ages 0-9 years, but there were no sex differences.

LIMITATIONS:

The study was limited to hospitalized children. We were unable to assess the impact of psoriasis treatment or family history on cardiovascular risk.

CONCLUSION:

Pediatric psoriasis is associated with higher odds of multiple cardiovascular comorbidities among hospitalized patients. Strategies for mitigating excess cardiovascular risk in pediatric psoriasis need to be determined.

KEYWORDS:

arrhythmia; cardiovascular risk factors; comorbidities; diabetes; hyperlipidemia; hypertension; obesity; psoriasis; racial differences

PMID:
28964537
PMCID:
PMC5685918
[Available on 2018-12-01]
DOI:
10.1016/j.jaad.2017.08.034
[Indexed for MEDLINE]

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