Format

Send to

Choose Destination
Magn Reson Imaging Clin N Am. 2017 Nov;25(4):779-785. doi: 10.1016/j.mric.2017.06.009. Epub 2017 Sep 8.

Safety of Contrast Material Use in Children.

Author information

1
Division of Pediatric Radiology and Pediatric Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 1800 Orleans Street, Zayed Tower, Room 4174, Baltimore, MD 21287, USA. Electronic address: bruno.soares@jhmi.edu.
2
Department of Radiology, University Medical Center, Heidelberglaan 100, Utrecht 3508 GA, The Netherlands.
3
Division of Pediatric Radiology and Pediatric Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 1800 Orleans Street, Zayed Tower, Room 4174, Baltimore, MD 21287, USA.

Abstract

Iodinated and gadolinium-based contrast materials have excellent safety profiles for use in pediatric computed tomography and MR imaging. The rate of acute adverse reactions and contrast-induced nephropathy is lower than in adults. The relationship between nephrogenic systemic fibrosis and gadolinium administration is well established and only a small number of children suffer from this debilitating disorder. The recent finding of gadolinium deposition in the brain of patients with normal renal function has renewed concerns regarding its long-term toxicity. The necessity of gadolinium-based contrast agent use in children should be considered carefully for each examination, and more stable macrocyclic agents should be the primary choice.

KEYWORDS:

Computed tomography; Contrast material; Gadolinium; Magnetic resonance imaging; Nephrogenic systemic fibrosis; Pediatric imaging

PMID:
28964467
DOI:
10.1016/j.mric.2017.06.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center