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J Mol Med (Berl). 2017 Dec;95(12):1283-1289. doi: 10.1007/s00109-017-1592-7. Epub 2017 Sep 30.

Interplay between circadian clock and viral infection.

Author information

1
Nuffield Department of Medicine, University of Oxford, Oxford, UK. xiaodong.zhuang@ndm.ox.ac.uk.
2
Institute for Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
3
Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Abstract

The circadian clock underpins most physiological conditions and provides a temporal dimension to our understanding of body and tissue homeostasis. Disruptions of circadian rhythms have been associated with many diseases, including metabolic disorders and cancer. Recent literature highlights a role for the circadian clock to regulate innate and adaptive immune functions that may prime the host response to infectious organisms. Viruses are obligate parasites that rely on host cell synthesis machinery for their own replication, survival and dissemination. Here, we review key findings on how circadian rhythms impact viral infection and how viruses modulate molecular clocks to facilitate their own replication. This emerging area of viral-clock biology research provides a fertile ground for discovering novel anti-viral targets and optimizing immune-based therapies.

KEYWORDS:

Circadian rhythms; Infectious disease; Viruses

PMID:
28963570
PMCID:
PMC5684296
DOI:
10.1007/s00109-017-1592-7
[Indexed for MEDLINE]
Free PMC Article

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