Format

Send to

Choose Destination
Nat Ecol Evol. 2017 Nov;1(11):1722-1730. doi: 10.1038/s41559-017-0318-0. Epub 2017 Sep 25.

Constrained vertebrate evolution by pleiotropic genes.

Author information

1
Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Society Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
2
School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
3
Department of Biological Sciences, University of Tokyo, Tokyo, 113-0033, Japan.
4
Institute for Integrative Neurobiology and Department of Biology, Faculty of Science and Engineering, Konan University, Kobe, Japan.
5
Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 115, Taiwan.
6
China National GeneBank, BGI-Shenzhen, Shenzhen, 518083, China.
7
Evolutionary Morphology Laboratory, RIKEN, Kobe, 650-0047, Japan.
8
Department of Bioinformatics and Systems Biology, School of Science, University of Tokyo, Tokyo, 113-0032, Japan.
9
Bioinformatics Research Unit, Advanced Center for Computing and Communication, RIKEN, Saitama, 351-0198, Japan.
10
Centre for Social Evolution, Department of Biology, University of Copenhagen, Copenhagen, DK-2200, Denmark.
11
Department of Biological Sciences, University of Tokyo, Tokyo, 113-0033, Japan. irie@bs.s.u-tokyo.ac.jp.
12
Universal Biology Institute, University of Tokyo, Tokyo, 113-0033, Japan. irie@bs.s.u-tokyo.ac.jp.

Abstract

Despite morphological diversification of chordates over 550 million years of evolution, their shared basic anatomical pattern (or 'bodyplan') remains conserved by unknown mechanisms. The developmental hourglass model attributes this to phylum-wide conserved, constrained organogenesis stages that pattern the bodyplan (the phylotype hypothesis); however, there has been no quantitative testing of this idea with a phylum-wide comparison of species. Here, based on data from early-to-late embryonic transcriptomes collected from eight chordates, we suggest that the phylotype hypothesis would be better applied to vertebrates than chordates. Furthermore, we found that vertebrates' conserved mid-embryonic developmental programmes are intensively recruited to other developmental processes, and the degree of the recruitment positively correlates with their evolutionary conservation and essentiality for normal development. Thus, we propose that the intensively recruited genetic system during vertebrates' organogenesis period imposed constraints on its diversification through pleiotropic constraints, which ultimately led to the common anatomical pattern observed in vertebrates.

PMID:
28963548
DOI:
10.1038/s41559-017-0318-0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center