Format

Send to

Choose Destination
J Thorac Oncol. 2017 Dec;12(12):1755-1765. doi: 10.1016/j.jtho.2017.09.1956. Epub 2017 Sep 27.

Management of Progressive Pulmonary Nodules Found during and outside of CT Lung Cancer Screening Studies.

Author information

1
Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Mannheim, Germany. Electronic address: mathias.meyer@medma.uni-heidelberg.de.
2
Center for Medical Imaging North-East Netherlands, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
3
Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Mannheim, Germany.
4
Department of Radiation Oncology, University Medical Center Mannheim, Mannheim, Germany.
5
Section of Oncology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.
6
University Medical School of Perugia, Azienda Ospedale Perugia, Perugia, Italy.
7
Department of Pulmonology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.
8
The Royal Brompton Hospital, London, United Kingdom.
9
University Hospitals Leicester, Leicester, United Kingdom.
10
Department of Thoracic Surgery, Tenon Hospital, Paris, France.
11
Department of Medicine, Thoracic Oncology Centre Munich Ludwig Maximilians University, Deutsches Zentrum für Lungenforschung (Comprehensive Pneumology Center Munich), Munich, Germany.
12
Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Białystok, Poland.
13
Department of Radiation Oncology, Centre Hospitalier Lyon Sud, Lyon, France.
14
Department of Oncology, University of Turin, Turin, Italy.
15
Department of Biostatistics, University Medical Center Mannheim, Mannheim, Germany.
16
Department of Radiation Oncology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.
17
Sotiria General Hospital, Athens School of Medicine, Athens, Greece.
18
Department of Medical Oncology, Léon Bérard Cancer Center, Lyon, France.
19
Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
20
Department for Diagnostic and Interventional Radiology, Eberhard Karls University Tübingen, University Hospital Tübingen, Tübingen, Germany.
21
Thoracic Oncology/Multidisciplinary Oncologic Centre, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.
22
Asbestos Diseases Research Institute, University of Sydney, Sydney, New South Wales, Australia.
23
Department of Lung Cancer and Immunology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Wuhan, People's Republic of China.
24
Division of Surgical Oncology and Thoracic Surgery, Department of Surgery, University Medical Center Mannheim, Mannheim, Germany.
25
Medical Innovation and Management, Steinbeis University Berlin, Germany.

Abstract

Although the effectiveness of screening for lung cancer remains controversial, it is a fact that most lung cancers are diagnosed at an advanced stage outside of lung cancer screening programs. In 2013, the U.S. Preventive Services Task Force revised its lung cancer screening recommendation, now supporting lung cancer screening by low-dose computed tomography in patients at high risk. This is also endorsed by many major medical societies and advocacy group stakeholders, albeit with different eligibility criteria. In Europe, population-based lung cancer screening has so far not been recommended or implemented, as some important issues remain unresolved. Among them is the open question of how enlarging pulmonary nodules detected in lung cancer screening should be managed. This article comprises two parts: a review of the current lung cancer screening approaches and the potential therapeutic options for enlarging pulmonary nodules, followed by a meeting report including consensus statements of an interdisciplinary expert panel that discussed the potential of the different therapeutic options.

KEYWORDS:

Lung cancer screening; Pulmonary nodules; Stereotactic ablative radiotherapy; Surgery

PMID:
28962947
DOI:
10.1016/j.jtho.2017.09.1956
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center