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Neurochem Int. 2017 Nov;110:91-100. doi: 10.1016/j.neuint.2017.09.012. Epub 2017 Sep 27.

Treadmill exercise alleviated prenatal buprenorphine exposure-induced depression in rats.

Author information

1
Department of Anesthesiology, Taichung Veterans General Hospital, Taichung City 407, Taiwan; Department of Financial and Computational Mathematics, Providence University, Taichung City 433, Taiwan.
2
Department of Anesthesiology, Taichung Veterans General Hospital, Taichung City 407, Taiwan.
3
Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung City 407, Taiwan.
4
Division of Family Medicine, Taichung Veterans General Hospital, Taichung City 407, Taiwan.
5
Department of Surgery, Feng Yuan Hospital, Taichung City 420, Taiwan.
6
Department of Veterinary Medicine, National Chung Hsing University, Taichung City 402, Taiwan.
7
Department of Medical Research, Taichung Veterans General Hospital, Taichung City 407, Taiwan.
8
Department of Medical Research, Taichung Veterans General Hospital, Taichung City 407, Taiwan; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung City 404, Taiwan. Electronic address: cjchen@vghtc.gov.tw.

Abstract

Mounting evidence suggests that physical exercise shows health benefits in a range of diseases, including psychiatric disorders. Perinatal opioid exposure produces neurobehavioral abnormality, which includes depression symptoms, in patients and their offspring following chronic use of buprenorphine, a mixed agonist/antagonist with a high affinity to opioid receptors, for pain control. Previously, we demonstrated that prenatal buprenorphine exposure in pregnant Sprague-Dawley rats starting from gestation day 7 and lasting for 14 days caused the development of depression-like phenotypes in pups at postnatal day 21. Using the same prenatal buprenorphine exposure model, we further demonstrated that a 4-week course of moderate treadmill exercise conducted on pups starting from postnatal day 22 improved depression-like neurobehaviors. Prenatal buprenorphine exposure-induced neurobehavioral changes were accompanied by reductions of neuronal survival, neural stem cell-associated genes, plasma level of brain-derived neurotrophic factor (BDNF) and serotonin, phosphorylated tropomyosin-related kinase receptor type B (TrkB), phosphorylated extracellular signal-regulated kinase (ERK), PKA activity, phosphorylated cAMP response element-binding protein (CREB), and CREB DNA binding activity, as well as elevation of repressor element-1 silencing transcription factor (REST), oxidative stress, and inflammatory responses. Those changes in parameters of plasma and brain were improved by treadmill exercise. In conclusion, the findings of the current study suggest that a non-pharmacological option, i.e., moderate treadmill exercise, alleviated the development of depression-like neurobehaviors by resolving the oxidative and inflammatory burden as well as by enhancing neurochemical and neuroendocrine signaling.

KEYWORDS:

Depression; Neuroendocrine; Neurotrophin; Opioid; Treadmill exercise

PMID:
28962922
DOI:
10.1016/j.neuint.2017.09.012
[Indexed for MEDLINE]

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