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Neurol Clin. 2017 Nov;35(4):601-611. doi: 10.1016/j.ncl.2017.06.001.

Anoxic-Ischemic Brain Injury.

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Department of Neurology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address:


Improvements in cardiopulmonary resuscitation and intensive care medicine have led to declining mortality rates for patients with out-of-hospital cardiac arrest, but overall it is still a minority that achieves good outcomes. Estimating neurologic prognosis for patients that remain comatose after resuscitation remains a challenge and the need for accurate and early prognostic predictors is crucial. A thoughtful approach is required and should take into account information acquired from multiple tests in association with neurologic examination. No decision should be made based on a single predictor. In addition to clinical examination, somatosensory evoked potentials, electroencephalogram, serum biomarkers, and neuroimaging provide complimentary information to inform prognosis.


Anoxic-ischemic brain injury; Cardiac arrest; Coma; Prognostication

[Indexed for MEDLINE]

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