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Head Neck. 2017 Dec;39(12):2528-2536. doi: 10.1002/hed.24930. Epub 2017 Sep 28.

Deregulation of selected microRNAs in sinonasal carcinoma: Value of miR-21 as prognostic biomarker in sinonasal squamous cell carcinoma.

Author information

1
Institute for Clinical Biochemistry and Diagnostics, Charles University, Faculty of Medicine, Hradec Kralove and University Hospital Hradec Kralove, Czech Republic.
2
The Fingerland Department of Pathology, Charles University, Faculty of Medicine, Hradec Kralove and University Hospital Hradec Kralove, Czech Republic.
3
Department of Oncology and Radiotherapy, Charles University, Faculty of Medicine, Hradec Kralove and University Hospital Hradec Kralove, Czech Republic.
4
Department of Pathology, Charles University, First Faculty of Medicine and General University Hospital in Prague, Czech Republic.
5
Department of Clinical and Molecular Pathology, Palacky University Olomouc, Faculty of Medicine and Dentistry and University Hospital Olomouc, Czech Republic.

Abstract

BACKGROUND:

Tumors occurring in the sinonasal area are characterized by unfavorable outcome due to difficult diagnosis, treatment, and prognosis of the disease corresponding with the anatomic complexity of the area.

METHODS:

We used quantitative real-time polymerase chain reaction (PCR) to compare relative expression of miR-21, miR-141, and miR-200c in 70 formalin-fixed, paraffin-embedded samples of sinonasal carcinoma tissue (majority of squamous cell carcinoma [SCC] samples) with 17 control samples of sinonasal tissue.

RESULTS:

Our data showed significant upregulation of miR-21 in sinonasal cancer tissue. Expression levels of miR-141 and miR-200c were below detectable levels in both sinonasal cancer samples and healthy tissue. Kaplan-Meier analysis with log-rank survival showed that patients with SCC with high expression of miR-21 (highest quartile) had impaired survival close to reaching statistical significance (P = .0630).

CONCLUSION:

Our results suggest that miR-21 upregulation is involved in tumorigenesis of sinonasal carcinoma and that it is associated with poor prognosis. Thus, miR-21 could be used as a valuable prognostic biomarker.

KEYWORDS:

biomarker; head and neck cancer; miR-21; microRNA; sinonasal carcinoma

PMID:
28960576
DOI:
10.1002/hed.24930
[Indexed for MEDLINE]

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