Format

Send to

Choose Destination
Proteins. 2018 Mar;86 Suppl 1:27-50. doi: 10.1002/prot.25392. Epub 2017 Oct 16.

Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016).

Author information

1
Genome Center, University of California, Davis, 451 Health Sciences Drive, Davis, California, 95616.
2
Department of Protein Evolution, Max Planck Institute for Developmental Biology, Tübingen, 72076, Germany.
3
Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom.
4
CIISA - Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade Técnica, 1300-477, Portugal, Lisboa.
5
Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England, United Kingdom.
6
UCIBIO, REQUIMTE, Departamento de Química, Faculdade de Cien⁁cias e Tecnologia, Universidade Nova de Lisboa, Caparica, 2829-516, Portugal.
7
Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, 20850.
8
Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
9
Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen Ø, Denmark.
10
Department of Molecular Biology and Biochemistry/Pharmaceutical Sciences, University of California Irvine, Irvine, California, 92697.
11
Department of Molecular, Cellular and Developmental Biology/Biomolecular Science and Engineering Program, University of California, Santa Barbara, Santa Barbara, California, 93106.
12
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, 20742.
13
Argonne National Laboratory, Midwest Center for Structural Genomics/Structural Biology Center, Biosciences Division, Argonne, Illinois, 60439.
14
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, 60637.
15
Microbiology, Saarland University, Campus Building A1.5, Saarbrücken, Saarland, D-66123, Germany.
16
Netherlands Centre for Electron Nanoscopy, Institute of Biology Leiden, Leiden University, 2333, CC Leiden, The Netherlands.
17
Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.
18
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano, 20126, Italy.
19
Department of Cell Biology and Molecular genetics, University of Maryland, 9600 Gudelsky Drive, Institute for Bioscience and Biotechnology Research, Rockville, Maryland, 20850.
20
Department of Biosciences, University of Milano, Milano, 20133, Italy.
21
Department of Macromolecular Structures, Centro Nacional de Biotecnologia (CSIC), calle Darwin 3, Madrid, 28049, Spain.
22
Université de Lyon, Centre de RMN à Très Hauts Champs, Institut des Sciences Analytiques (UMR 5280 - CNRS, ENS Lyon, UCB Lyon 1), Villeurbanne, 69100, France.
23
University of Maryland School of Medicine, Institute of Human Virology, Baltimore, Maryland, 21201.
24
Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Henry Wellcome Building, University Road, Leicester, LE1 7RN, UK.
25
School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, United Kingdom.
26
Department of Medicine and Department of Microbiology and Immunology, University of Maryland School of Medicine, Institute of Human Virology, Baltimore, Maryland, 21201.
27
Latvian Biomedical Research and Study Center, Rātsupītes 1, Riga, LV1067, Latvia.
28
Faculty of Biology, Department of Molecular Biology, University of Latvia, Jelgavas 1, Riga, LV-1004, Latvia.
29
Biozentrum/SIB Swiss Institute of Bioinformatics, Klingelbergstrasse 50, Basel, 4056, Switzerland.

Abstract

The functional and biological significance of the selected CASP12 targets are described by the authors of the structures. The crystallographers discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submitted to the CASP12 experiment.

KEYWORDS:

CASP; NMR; X-ray crystallography; protein structure prediction

PMID:
28960539
PMCID:
PMC5820184
[Available on 2019-03-01]
DOI:
10.1002/prot.25392
Free full text

Supplemental Content

Full text links

Icon for Wiley Icon for Archivio Istituzionale della Ricerca Unimi
Loading ...
Support Center