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Psychopharmacology (Berl). 1988;94(3):298-301.

GABA agonists in cebus monkeys with neuroleptic-induced persistent dyskinesias.

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1
Psychiatric Research Center, University of Uppsala, Sweden.

Abstract

Tetrahydroisoxazolopyridinol (THIP), a GABA receptor agonist, gamma-acetylenic-GABA(GAG) and gamma-vinyl-GABA(GVG), two GABA transaminase inhibitors were given in single parenteral doses to three Cebus apella monkeys with persistent dyskinetic movements induced by earlier long-term administration of haloperidol. High doses of THIP temporarily abolished dyskinesias but also caused bradykinesia, ataxia, dystonia and myoclonic jerks. GAG and GVG reduced dyskinesias to a lesser extent and with fewer side effects. Whether the observed antidyskinetic effect is secondary to the concomitant general toxic effects or if these drugs have a specific antidyskinetic action remains an open question.

PMID:
2895937
[Indexed for MEDLINE]

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