Format

Send to

Choose Destination
Trends Parasitol. 2018 Jan;34(1):64-79. doi: 10.1016/j.pt.2017.08.011. Epub 2017 Sep 22.

Onchocerca volvulus: The Road from Basic Biology to a Vaccine.

Author information

1
Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY, USA. Electronic address: slustigman@nybloodcenter.org.
2
Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
3
Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
4
Institute of Biodiversity, Animal Health & Comparative Medicine, College of Medical, Veterinary & Life Sciences, University of Glasgow and Moredun Research Institute, Glasgow, UK.
5
Texas Children's Hospital Center for Vaccine Development, Department of Pediatrics, Section of Pediatric Tropical Medicine, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
6
Department of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

Abstract

Human onchocerciasis - commonly known as river blindness - is one of the most devastating yet neglected tropical diseases, leaving many millions in sub-Saharan Africa blind and/or with chronic disabilities. Attempts to eliminate onchocerciasis, primarily through the mass drug administration of ivermectin, remains challenging and has been heightened by the recent news that drug-resistant parasites are developing in some populations after years of drug treatment. Needed, and needed now, in the fight to eliminate onchocerciasis are new tools, such as preventive and therapeutic vaccines. This review summarizes the progress made to advance the onchocerciasis vaccine from the research laboratory into the clinic.

KEYWORDS:

Onchocerca volvulus; elimination; vaccine; vaccine candidates

PMID:
28958602
PMCID:
PMC5748257
DOI:
10.1016/j.pt.2017.08.011
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center