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Food Chem. 2018 Feb 15;241:182-187. doi: 10.1016/j.foodchem.2017.08.072. Epub 2017 Aug 30.

Antioxidant phenolic compounds isolated from wild Pyrus ussuriensis Maxim. fruit peels and leaves.

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College of Plant Science, Jilin University, Changchun, Jilin 130062, PR China.
Pathology and Pathophysiology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, Zhejiang A&F University, Lin'an, Zhejiang 311300, China.
Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Centre for Wood Science, Department of Biology, University of Hamburg, Leuschnerstrasses 91, Hamburg 21031, Germany.
College of Plant Science, Jilin University, Changchun, Jilin 130062, PR China. Electronic address:


Thirteen phenolic compounds were isolated from pear (Pyrus ussuriensis Maxim.) peels and leaves extracts by using various column chromatography techniques with a guided DPPH (1,1-diphenyl-2-picrylhydrazyl) radical-scavenging assay, the result of antioxidant activity of phenolic compounds is then verified by measurement of ROS (reactive oxygen species). The isolated compounds were identified as rutin (1), (-)-catechin (2), orobol (3), daidzein (4), tricin 4'-O-[threo-β-guaiacyl-(7″-O-methyl)-glyceryl] ether (5), tricin 4'-O-[threo-β-guaiacyl-(7″-O-methyl-9″-O-acetyl)-glyceryl] ether (6), 5,7,3',5'-tetrahydroxyflavanone (7), artselaeroside A (8), trilobatin (9), 3-(2,4,6-trihydroxyphenyl)-1-(4-hydroxyphenyl)-propan-1-one (10), quercetin-3-O-(3″-O-galloyl)-α-l-rhamnopyranoside (11), apigenin (12) and quercetin (13) on the basis of nuclear magnetic resonance spectroscopy along with comparison with literature data. Among these compounds, quercetin and quercetin-3-O-(3″-O-galloyl)-α-l-rhamnopyranoside exhibited potent DPPH radical-scavenging activity with IC50 (Half Maximal Inhibitory Concentration) value of 6.06 and 9.60μg/mL, respectively. The results revealed that P. ussuriensis could be used in the fields of food and medicine to prevent human aging diseases.


(−)-Catechin (2) (PubChem CID: 73160); 3-(2,4,6-Trihydroxyphenyl)-1-(4-hydroxyphenyl)-propan-1-one (10) (PubChem CID: 70018969); 5,7,3′,5′-Tetrahydroxyflavanone (7) (PubChem CID: 11483087); Antioxidant activities; Apigenin (12) (PubChem CID: 5280443); Artselaeroside A (8) (PubChem CID: 100930979); Bioactive compounds; Daidzein (4) (PubChem CID: 5281708); Orobol (3) (PubChem CID: 5281801); Phenolic compounds; Phytochemical; Pyrus ussuriensis Maxim.; Quercetin (13) (PubChem CID: 5280343); Quercetin-3-O-(3″-O-galloyl)-α-l-rhamnopyranoside (11) (PubChem CID: 23786426); Rutin (1) (PubChem CID: 5280805); Tricin 4′-O-[threo-β-guaiacyl-(7″-O-methyl)-glyceryl] ether (5) (PubChem CID: 49785092); Tricin 4′-O-[threo-β-guaiacyl-(7″-O-methyl-9″-O-acetyl)-glyceryl] ether (6) (PubChem CID:12986874); Trilobatin (9) (PubChem CID: 6451798)

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