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ACS Appl Mater Interfaces. 2017 Oct 25;9(42):36665-36674. doi: 10.1021/acsami.7b12949. Epub 2017 Oct 10.

Flexible Nanoholey Patches for Antibiotic-Free Treatments of Skin Infections.

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Université de Lille, CNRS, Centrale Lille, ISEN, Université de Valenciennes, UMR 8520-IEMN, F-59000 Lille, France.
Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University , Jinan 250061, China.
Institute of Information and Communication Technologies, Electronics and Applied Mathematics, Université catholique de Louvain , 1348 Louvain-la-Neuve, Belgium.
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF), UMR 8576 du CNRS et Université de Lille, 50 Av. de Halley, 59658 Villeneuve d'Ascq, France.
Graphenea S.A., Tolosa Hiribidea 76, 20018 Donostia, San Sebastian, Spain.
Institut Charles Viollette, Université de Lille1 , EA 7394 Lille, France.
Danylo Halytsky Lviv National Medical University , 79010 Lviv, Ukraine.


Despite the availability of different antibiotics, bacterial infections are still one of the leading causes of hospitalization and mortality. The clinical failure of antibiotic treatment is due to a general poor antibiotic penetration to bacterial infection sites as well as the development of antibiotic-resistant pathogens. In the case of skin infection, the wound is covered by exudate, making it impermeable to topical antibiotics. The development of a flexible patch allowing a rapid and highly efficient treatment of subcutaneous wound infections via photothermal irradiation is presented here. The skin patch combines the near-infrared photothermal properties of a gold nanohole array formed by self-assembly of colloidal structures on flexible polyimide films with that of reduced graphene oxide nanosheets for laser-gated pathogen inactivation. In vivo tests performed on mice with subcutaneous skin infection and treated with the photothermal skin patch show wound healing of the infected site, while nontreated areas result in necrotic muscular fibers and bacterial infiltrate. No loss in efficiency is observed upon multiple use of these patches during in vivo experiments because of their robustness.


bacteria ablation; gold nanoholes; in vivo treatment; photothermal therapy; polyimide; reduced graphene oxide; wound infection

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