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Angiology. 2017 Nov;68(10):877-883. doi: 10.1177/0003319717696622. Epub 2017 Mar 10.

Predictive Nomogram of RAGE Genetic Polymorphisms and Metabolic Risk Factors for Myocardial Infarction Risk in a Han Chinese Population.

Author information

1
1 Heart Center, Beijing Chao Yang Hospital, Capital Medical University, Beijing, China.
2
The first two authors (Weiming Li and Yingxue Li) contributed equally to this work.
3
2 Department of Internal Medicine, The Second Hospital of Tangshan, Tangshan, Hebei, China.
4
3 Department of Cardiology, Tangshan Gongren Hospital, Tangshan, Hebei, China.

Abstract

We investigated the association of 4 well-characterized polymorphisms in receptor for the advanced glycation end-product ( RAGE) gene with myocardial infarction (MI) risk and the changes in metabolic risk factors among 717/612 patients/controls, with the aim of constructing a predictive nomogram. The genotype/allele distributions differed significantly between the 2 groups for T-429C ( Pgenotype/allele = .004/.001) and G1704T ( P < .001/.001). T-429C was significantly associated with MI risk, especially under a recessive model (adjusted odds ratio: 2.24, 95% confidence interval: 1.33-3.79, P = .003). For G1704T, significance was detected under additive (1.37; 1.12-1.67; P = .002) and recessive (3.86; 2.27-6.57; P < .001) models. There were significant differences in blood pressure and low-density lipoprotein cholesterol (LDL-C) across T-429C genotypes and in total cholesterol and LDL-C across G1704T genotypes. The overall best multifactor dimensionality reduction model included dyslipidemia, G1704T, and T-429C. Further predictive nomogram on 2 significant polymorphisms, blood pressure and lipids, showed a better predictive capability (concordance index = 0.716, P < .001). Altogether, we identified 2 polymorphisms of RAGE, T-429C and G1704T, which interacted with metabolic risk factors associated with the occurrence of MI. We also constructed a genetic-metabolic nomogram that can better predict MI risk.

KEYWORDS:

RAGE; interaction; metabolic risk factor; myocardial infarction; nomogram

PMID:
28956473
DOI:
10.1177/0003319717696622
[Indexed for MEDLINE]

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