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Nutrients. 2017 Sep 26;9(10). pii: E1060. doi: 10.3390/nu9101060.

Therapeutic Effects of Olive and Its Derivatives on Osteoarthritis: From Bench to Bedside.

Author information

1
Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Malaysia. chinkokyong@ppukm.ukm.edu.my.
2
Biomedical Science Programme, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia. pangkoklun@gmail.com.

Abstract

Osteoarthritis is a major cause of morbidity among the elderly worldwide. It is a disease characterized by localized inflammation of the joint and destruction of cartilage, leading to loss of function. Impaired chondrocyte repair mechanisms, due to inflammation, oxidative stress and autophagy, play important roles in the pathogenesis of osteoarthritis. Olive and its derivatives, which possess anti-inflammatory, antioxidant and autophagy-enhancing activities, are suitable candidates for therapeutic interventions for osteoarthritis. This review aimed to summarize the current evidence on the effects of olive and its derivatives, on osteoarthritis and chondrocytes. The literature on animal and human studies has demonstrated a beneficial effect of olive and its derivatives on the progression of osteoarthritis. In vitro studies have suggested that the augmentation of autophagy (though sirtuin-1) and suppression of inflammation by olive polyphenols could contribute to the chondroprotective effects of olive polyphenols. More research and well-planned clinical trials are required to justify the use of olive-based treatment in osteoarthritis.

KEYWORDS:

autophagy; cartilage; chondrocyte; hydroxytyrosol; inflammation; joint; oleocanthal; oleuropein; sirtuin-1; tyrosol

PMID:
28954409
PMCID:
PMC5691677
DOI:
10.3390/nu9101060
[Indexed for MEDLINE]
Free PMC Article

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