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Nutrients. 2017 Sep 27;9(10). pii: E1072. doi: 10.3390/nu9101072.

Animal Models of Nonalcoholic Fatty Liver Disease-A Starter's Guide.

Author information

1
Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology and Hepatology, University of Antwerp, 2610 Antwerp, Belgium. mikhail.vanherck@uantwerpen.be.
2
Department of Gastroenterology and Hepatology, Antwerp University Hospital, 2650 Edegem, Belgium. mikhail.vanherck@uantwerpen.be.
3
Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology and Hepatology, University of Antwerp, 2610 Antwerp, Belgium. luisa.vonghia@uza.be.
4
Department of Gastroenterology and Hepatology, Antwerp University Hospital, 2650 Edegem, Belgium. luisa.vonghia@uza.be.
5
Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology and Hepatology, University of Antwerp, 2610 Antwerp, Belgium. sven.francque@uza.be.
6
Department of Gastroenterology and Hepatology, Antwerp University Hospital, 2650 Edegem, Belgium. sven.francque@uza.be.

Abstract

Nonalcoholic fatty liver disease (NAFLD) constitutes a major health concern with the increasing incidence of obesity and diabetes in many Western countries, reaching a prevalence of up to 30% in the general population. Animal models have played a vital role in elucidating the pathophysiological mechanisms of NAFLD and continue to do so. A myriad of different models exists, each with its advantages and disadvantages. This review presents a brief overview of these models with a particular focus on the basic mechanisms and physical, biochemical and histological phenotype. Both nutritional and chemically induced, as well as genetic models are examined, including models combining different approaches.

KEYWORDS:

animal model; fibrosis; hepatocellular carcinoma; high-fat diet; mouse; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; rat

PMID:
28953222
PMCID:
PMC5691689
DOI:
10.3390/nu9101072
[Indexed for MEDLINE]
Free PMC Article

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