Format

Send to

Choose Destination
Pharmacogenomics. 2017 Nov;18(16):1503-1513. doi: 10.2217/pgs-2017-0127. Epub 2017 Sep 27.

Influence of CYP3A and ABCB1 polymorphisms on cyclosporine concentrations in renal transplant recipients.

Author information

1
Department of Pharmacy, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China.
2
Department of Renal Transplantation & Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China.

Abstract

AIM:

Cyclosporine is a substrate of CYP3A and ABCB1. This study examined the role of CYP3A and ABCB1 polymorphisms on cyclosporine pharmacokinetics in renal transplant recipients.

PATIENTS & METHODS:

CYP3A and ABCB1 SNPs were detected in 521 recipients. The relationships of dose-adjusted concentrations with corresponding genotypes were investigated at the different terms.

RESULTS:

CYP3A5 rs776746 and CYP3A7 rs10211 genotype affect C0/D at the short-term, medium-term and long-term after transplantation (p < 0.05). CYP3A7 rs2257401 genotype affects C2/D at the medium-term (p < 0.05). CYP3A4 rs4646437, CYP3A5 rs776746 and CYP3A7 rs2257401 genotype affect C2/D at the long-term (p < 0.05). There are no relationships between ABCB1 polymorphism and cyclosporine C/D.

CONCLUSION:

CYP3A genetic factors (rs776746, rs4646437, rs2257401 and rs10211) were varied in different stages after transplantation. The role of CYP3A7 in cyclosporine metabolism requires further study.

KEYWORDS:

ABCB1; CYP3A; cyclosporine; dose-adjusted concentration; gene polymorphisms; individualized therapy; renal transplant recipient

PMID:
28952408
DOI:
10.2217/pgs-2017-0127
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center