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J Diabetes Res. 2017;2017:7047909. doi: 10.1155/2017/7047909. Epub 2017 Aug 16.

Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study.

Author information

1
Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea.
2
Department of Internal Medicine, Busan St. Mary's Medical Center, Busan, Republic of Korea.
3
Department of Internal Medicine, Woori Medical Clinic, Busan, Republic of Korea.
4
Department of Internal Medicine, Bongseng Memorial Hospital, Busan, Republic of Korea.
5
Department of Internal Medicine, Ilsin Christian Hospital, Busan, Republic of Korea.
6
Department of Internal Medicine, Good Moonhwa Hospital, Busan, Republic of Korea.
7
Department of Internal Medicine, Daedong Hospital, Busan, Republic of Korea.
8
Department of Internal Medicine, College of Medicine, Pusan Paik Hospital, Inje University, Busan, Republic of Korea.

Abstract

AIM:

The aim of this study was to evaluate the association between arterial stiffness and albuminuria and glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus.

METHODS:

This multicenter cohort study analyzed 2613 patients with type 2 diabetes. Brachial-ankle pulse wave velocity (baPWV) was used as a noninvasive marker of arterial stiffness. Additionally, the patients were categorized into four groups according to their albumin-to-creatinine ratio (ACR, normoalbuminuria versus albuminuria) and estimated GFR (eGFR, <60 mL/min/1.73 m2 versus ≥60 mL/min/1.73 m2).

RESULTS:

A univariate analysis revealed that maximal baPWV was significantly associated with both the ACR (r = 0.297, P < 0.001) and eGFR (r = -0.220, P < 0.001). A multivariate analysis adjusted for significant clinical variables and eGFR showed that baPWV remained significantly correlated with the ACR (r = 0.150, P < 0.001). Also, baPWV was correlated positively with the ACR in patients with an eGFR ≥ 60 mL/min/1.73 m2 (r = 0.146, P < 0.001). However, baPWV was not correlated with eGFR after adjustment for significant clinical variables.

CONCLUSIONS:

The present findings indicate that arterial stiffness is more associated with albuminuria than a decrease in GFR in patients with type 2 diabetes mellitus.

PMID:
28951879
PMCID:
PMC5603750
DOI:
10.1155/2017/7047909
[Indexed for MEDLINE]
Free PMC Article

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