Format

Send to

Choose Destination
J Mov Disord. 2017 Sep;10(3):123-129. doi: 10.14802/jmd.17048. Epub 2017 Sep 22.

Sleepiness and Depression in Parkinson's Disease Patients Treated with Ropinirole and Levodopa.

Author information

1
Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.
2
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
3
Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, Korea.
4
Department of Neurology, Inje University College of Medicine, Busan, Korea.
5
Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
6
Department of Neurology, Yeungnam University Medical Center, Daegu, Korea.
7
Department of Neurology Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
8
Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine, Seoul, Korea.
9
Department of Neurology, Korea University College of Medicine, Korea University Guro Hospital, Seoul, Korea.
10
Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
11
Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
12
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.

Abstract

OBJECTIVE:

We aimed to investigate the effect of ropinirole on excessive daytime sleepiness (EDS) and depression in Parkinson's disease (PD) with a large population.

METHODS:

We conducted a cross-sectional observational study at nine hospitals in Korea between April 24, 2013, and April 22, 2015. We analyzed the demographic and clinical features, other medical history, history of antiparkinsonian medication within 6 months, Hoehn and Yahr stage (HY stage), Unified Parkinson's Disease Rating Scale (UPDRS) part II and III, Epworth Sleepiness Scale (ESS), and 30-item Geriatric Depression Scale (GDS-30).

RESULTS:

Four-hundred-thirteen patients with PD (mean age: 65.2 ± 9.0 years; men: 227 patients) were analyzed. Multivariate logistic regression analysis showed that age at examination, UPDRS II, and GDS-30 were independent risk factors for EDS and that sex, UPDRS II, and ESS were independent risk factors for depression.

CONCLUSION:

Our large group study did not find any significant associations of ropinirole with EDS and depression in Korean PD patients.

KEYWORDS:

Parkinson’s disease; depression; excessive daytime sleepiness; levodopa; mood; ropinirole; sleepiness

Supplemental Content

Full text links

Icon for Publishing M2Community Icon for PubMed Central
Loading ...
Support Center