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Discov Med. 2017 Aug;24(130):7-18.

The Hippo signaling pathway: an emerging anti-cancer drug target.

Tao Y1,2, Cai F3,2, Shan L1, Jiang H1, Ma L3, Yu Y1.

Author information

1
Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China.
2
These authors contributed equally to this article.
3
Department of Clinical Laboratory Medicine, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China.

Abstract

The Hippo signaling is a highly conserved pathway that plays important roles in tumorigenesis, stem cell self-renewal and differentiation, organ size control, and many other biological processes. Functions of the Hippo signaling pathway are regulated by complicated intracellular and extracellular signaling networks. When activated, the Hippo pathway functions as a tumor suppressor. However, dysregulation of this pathway contributes to increased cell proliferation and decreased apoptosis and differentiation. Therefore, regulation of Hippo signaling by pharmacological modulators may be a promising anticancer strategy. Here, we summarize potential anti-cancer drugs that target components of the Hippo pathway or regulate interactions between the Hippo signaling pathway and other signaling pathways.

PMID:
28950071
[Indexed for MEDLINE]
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