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Chin Med J (Engl). 2017 Dec 5;130(23):2857-2862. doi: 10.4103/0366-6999.215500.

Vitamin D and Cardiovascular Risk in Children.

Author information

1
Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

Abstract

OBJECTIVE:

Vitamin D is a group of fat-soluble molecules that are structurally similar to steroids. Emerging data have led to the hypothesis that Vitamin D plays a role in the regulation of many physiological processes beyond calcium and phosphorus homeostasis. With this review, we aimed to summarize the changes in Vitamin D levels in children with cardiovascular diseases based on the literature. In addition, we also reviewed the potential mechanisms underlying cardiovascular diseases associated with Vitamin D deficiency or insufficiency.

DATA SOURCES:

The articles in English were searched from PubMed (1968-2016) and EMBASE (1991-2016), with the keywords of "Vitamin D AND cardiovascular diseases" and "Vitamin D AND children."

STUDY SELECTION:

Original articles and critical reviews about Vitamin D and cardiovascular risk in children were selected for review. Researches focused on adults were excluded.

RESULTS:

Studies have shown that several pediatric cardiovascular diseases may be associated with Vitamin D deficiency or insufficiency, including hypertension, orthostatic intolerance, and Kawasaki disease.

CONCLUSIONS:

Vitamin D may play a role in the regulation of the cardiovascular system. Further investigation would hopefully disclose the usefulness of Vitamin D as a biomarker for cardiovascular diseases in children.

PMID:
28948941
PMCID:
PMC5717866
DOI:
10.4103/0366-6999.215500
[Indexed for MEDLINE]
Free PMC Article

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