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Biochem Biophys Res Commun. 1988 Feb 29;151(1):32-9.

Isolation of mutants of Schizosaccharomyces pombe unable to synthesize cadystin, small cadmium-binding peptides.

Author information

1
Department of Genetics, Institute for Developmental Research, Aichi Prefectural Colony, Japan.

Abstract

Schizosaccharomyces pombe synthesize small cadmium-binding peptides cadystin, structure of which is (gamma-Glu-Cys)n-Gly, in response to cadmium. Mutants unable to synthesize cadystin were found in the mutants hypersensitive to cadmium. Some of them lack activity of either gamma-glutamylcysteine synthetase (EC 6.3.2.2) or glutathione synthetase (EC 6.3.2.3), enzyme involved in glutathione biosynthesis. Some mutants have the same activity levels of these enzymes as wild type has. These results indicate that some steps of cadystin biosynthesis are catalyzed by the enzymes catalyzing glutathione biosynthesis.

PMID:
2894829
DOI:
10.1016/0006-291x(88)90555-4
[Indexed for MEDLINE]

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