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Genes Dev. 2017 Aug 15;31(16):1615-1634. doi: 10.1101/gad.303776.117.

Lymphangiogenesis guidance by paracrine and pericellular factors.

Author information

1
Wihuri Research Institute, Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland.
2
Department of Immunology, Genetics, and Pathology, Uppsala University, 75185 Uppsala, Sweden.

Abstract

Lymphatic vessels are important for tissue fluid homeostasis, lipid absorption, and immune cell trafficking and are involved in the pathogenesis of several human diseases. The mechanisms by which the lymphatic vasculature network is formed, remodeled, and adapted to physiological and pathological challenges are controlled by an intricate balance of growth factor and biomechanical cues. These transduce signals for the readjustment of gene expression and lymphatic endothelial migration, proliferation, and differentiation. In this review, we describe several of these cues and how they are integrated for the generation of functional lymphatic vessel networks.

KEYWORDS:

VEGF-C; VEGFR3; interstitial fluid pressure; lymphangiogenesis; lymphatic vessel basement membrane; lymphatic vessel sprouting; lymphedema

PMID:
28947496
PMCID:
PMC5647933
DOI:
10.1101/gad.303776.117
[Indexed for MEDLINE]
Free PMC Article

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