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Acc Chem Res. 2017 Mar 21;50(3):644-646. doi: 10.1021/acs.accounts.6b00645.

Ultrastable Artificial Binding Pairs as a Supramolecular Latching System: A Next Generation Chemical Tool for Proteomics.

Author information

1
Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.
2
Department of Nanomaterials and Engineering, University of Science and Technology (UST) , Daejon 34113, Republic of Korea.
3
Department of Chemistry, Pohang University of Science and Technology , Pohang 37673, Republic of Korea.

Abstract

In this Commentary, we discuss cucurbit[7]uril-based ultrastable artificial binding pairs as a supramolecular latching system and how we envision this becoming important tools in proteomics. The limitations of current proteomic techniques are described with an emphasis on the lack of tools to answer questions about the complex and dynamic nature of the proteome. Our thoughts as to how artificial ultrastable binding pairs may be able to address these questions are given especially when they are combined with existing methods.

PMID:
28945411
DOI:
10.1021/acs.accounts.6b00645
[Indexed for MEDLINE]

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